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    As received Figure 5, ANA-TA9 was discovered in the CSF 10 min after i.n . It is noteworthy that the focus in the CSF after i.n . These findings clearly indicate that ANA-TA9 is supplied to the CSF straight, not through the systemic blood circulation.
    Given that the rapid decline in the plasma focus most likely impedes the accurate determination of the pharmacokinetic specifications, i.v. To make clear carefully the quick plasma clearance, an artificial insemination study of stability was conducted. The degradation of ANA-TA9 in the plasma and the entire blood was not as fast as the plasma clearance. Shot and the in vitro security is most likely due to the degradation of ANA-TA9 externally of vascular endothelial cells, whose area is much bigger than that of blood cells. From the point of view of stability in the blood, direct delivery from the nose to the mind is additionally useful over that from the systemic flow. As shown in Table 1, the nasal bioavailability of ANA-TA9 was 36.0 ± 4.65%, which appears higher than would certainly be anticipated from the molecular dimension and hydrophilicity of ANA-TA9.

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